منابع مشابه
Barriers to drug delivery in solid tumors
Over the last decade, significant progress has been made in the field of drug delivery. The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery such as pharmacokinetics and solubility. However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors still remains elusive. Tumors possess distin...
متن کاملSafe and Immunocompatible Nanocarriers Cloaked in RBC Membranes for Drug Delivery to Treat Solid Tumors
The therapeutic potential of nanoparticle-based drug carriers depends largely on their ability to evade the host immune system while delivering their cargo safely to the site of action. Of particular interest are simple strategies for the functionalization of nanoparticle surfaces that are both inherently safe and can also bestow immunoevasive properties, allowing for extended blood circulation...
متن کاملCombining two strategies to improve perfusion and drug delivery in solid tumors.
Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a hypoxic microenvironment. Hypoxia promotes tumor progression and immunosuppression, and enhances the invasive and metastatic potential of cancer cells. Furthermore, poor perfusi...
متن کاملBreaking barriers in transdermal drug delivery.
SINCE THE FIRST TRANSDERMAL patch was approved by the US Food and Drug Administration in 1979 to treat motion sickness, patches have become a useful means of delivering drugs for a number of purposes. Still, the barrier properties of the skin mean that currently only modest doses of small, lipophilic drugs can be effectively delivered through the skin. But new research reported by scientists at...
متن کاملEffect of tumor shape and size on drug delivery to solid tumors
: Tumor shape and size effect on drug delivery to solid tumors are studied, based on the application of the governing equations for fluid flow, i.e., the conservation laws for mass and momentum, to physiological systems containing solid tumors. The discretized form of the governing equations, with appropriate boundary conditions, is developed for predefined tumor geometries. The governing equat...
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ژورنال
عنوان ژورنال: Tissue Barriers
سال: 2014
ISSN: 2168-8370
DOI: 10.4161/tisb.29528